After receiving a generous grant from the American Medical Association to find a cure for cancer, Dr. Dyanesh Kripal Chawla aka Duke (Bobby Deol), always gives hope to his patients. When he proposes to his sweetheart, Pooja (Kangana Ranaut), she agrees and both arrange to get married soon. While returning home that night, he meets with an accident and wakes up in the East-West Hospital, paralyzed from the neck down with virtually no chance of recovery. Shattered and devastated, he is in for more trauma and shock when he finds out that Pooja will have nothing to do with him anymore. Upset, bitter and in despair, he loses his will to live, refuses to take medicine nor any treatment, and awaits death. Until he meets a young, terminally ill boy, who teaches him to live again.